Metabolism Alprazolam is thoroughly metabolized in human beings, mainly by cytochrome P450 3A4 (CYP3A4), to 2 important Energetic metabolites while in the plasma: 4-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation amounts of the two Lively metabolites are under 4% on the mum or dad. The documented relative potencies in benzodiazepi